The Broadway production was directed by Mike Ockrent and choreographed by Susan Stroman. After 10 previews, it opened at the Shubert Theatre on February 19, 1992, and ran for 1,622 performances. The cast included Jodi Benson as Polly, Harry Groener as Bobby Child, Bruce Adler as Bela Zangler, John Hillner as Lank Hawkins, Michele Pawk as Irene Roth, Jane Connell as Mother, Beth Leavel as Tess (Leavel also understudied Benson), Ronn Carroll as Everett Baker, and Stephen Temperley and Amelia White as Eugene and Patricia Fodor. The Manhattan Rhythm Kings played cowboys Mingo, Moose, and Sam, singing in their trademark close harmony.
In his review in The New York Times, Frank Rich wrote, "When future historians try to find the exact moment at which Broadway finally rose up to grab the musical back from the British, they just may conclude that the revolution began last night. The shot was fired at the Shubert Theater, where a riotously entertaining show called Crazy for You uncorked the American musical’s classic blend of music, laughter, dancing, sentiment and showmanship with a freshness and confidence rarely seen during the Cats decade . . . Crazy for You scrapes away decades of cabaret and jazz and variety-show interpretations to reclaim the Gershwins’ standards, in all their glorious youth, for the dynamism of the stage."
A cast album was released by Angel Records.
The West End production, directed by Ockrent, choreographed by Stroman, and starring Ruthie Henshall, Kirby Ward, and Chris Langham, opened at the Prince Edward Theatre on March 3, 1993 and ran for nearly three years.
On October 20, 1999, the PBS series Great Performances broadcast a production directed by Matthew Diamond, who was nominated for the Emmy Award for Outstanding Direction of a Variety or Music Program.
On October 18, 2009, a showtime challenge, charity gala performance of Crazy for You, directed by Katherine Hare and choreographed by Racky Plews was staged by Eyebrow Productions at the London Palladium. Eyebrow are well known for their unique Showtime Challenges, where all aspects of the show are rehearsed and performed in 48 hours. All proceeds went to Cecily's Fund.
In 2011, Regent's Park Open Air Theatre did a revival of Crazy for You as part of the 2011 Summer Season. The production has since moved to the West End, at the Novello Theatre where it is running from October 8, 2011 to July 28, 2012.