The musical premiered in San Diego, California on September 22, 2004, before moving to Broadway in January 2005 and officially opening in March at the Imperial Theatre. The show closed on Broadway on September 3, 2006 with a total of 626 performances. The director was Jack O'Brien, choreographer was Jerry Mitchell, scenic design by David Rockwell, costume design by Gregg carves, and lighting design was by Kenneth Posner. The cast included John Lithgow, Norbert Leo Butz, and Sherie Rene Scott, with Joanna Gleason and Gregory Jbara.
The Dirty Rotten Scoundrels: Original Broadway Cast Recording CD was recorded on March 14, 2005 at Right Track Studio in New York City and was released on May 10, 2005 by Ghostlight Records (an imprint of Sh-K-Boom Records).
A North American national Equity tour launched on August 4, 2006 with Norbert Leo Butz reprising his role as Freddy, alongside Tom Hewitt as Lawrence. The Equity tour ended on August 19, 2007. The 25-city non-Equity tour of the show, with Jamie Jackson as Lawrence and Doug Thompson as Freddy, debuted September 25, 2007 in Dayton, Ohio, with its final performance on March 23, 2008, in Memphis, Tennessee. International productions have opened in Tokyo, Mexico City, Madrid, Stuttgart, Seoul, Oslo, Stockholm, Tampere and productions are planned for Copenhagen, Reykjavik, and London.